# Acetylcholinesterase

Source: https://onco.cc/targets/da-target-ache/  
OnCo record `da-target-ache` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Blocking this enzyme is how donepezil, rivastigmine, and galantamine try to support signalling.

## Summary

The approach is symptomatic. It does not clear plaques or tangles.

## Fields

- Kind: Target
- Last checked: 2026-09-21
- Tags: dementia-atlas
- Symbol: ACHE
- Class: enzyme
- Biology: Enzyme that breaks down acetylcholine in the synaptic cleft.

## Sources

- NICE NG97: https://www.nice.org.uk/guidance/ng97

## Connected records

- drugs: [Donepezil](https://onco.cc/drugs/da-donepezil/), [Galantamine](https://onco.cc/drugs/da-galantamine/), [Rivastigmine](https://onco.cc/drugs/da-rivastigmine/)
- diagnoses: [Alzheimer’s disease](https://onco.cc/diagnoses/alzheimers-disease/), [Dementia with Lewy bodies](https://onco.cc/diagnoses/dementia-with-lewy-bodies/), [Parkinson’s disease dementia](https://onco.cc/diagnoses/parkinsons-disease-dementia/)

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JSON: https://onco.cc/api/v1/entities/da-target-ache.json