{"entity":{"id":"da-idea-inclusive-anti-amyloid-trials","kind":"idea","name":"Antibody trials that enrol mixed and comorbid disease","aka":[],"tldr":"Test amyloid antibodies in the mixed, comorbid people clinics actually see, instead of only in tidy trial cohorts.","summary":"Until that trial exists, labels and MRI rules should stay conservative. This idea is a proposed test, not a reason to ignore exclusions.","asOf":"2026-09-21","links":[{"label":"ClinicalTrials.gov","url":"https://clinicaltrials.gov"}],"tags":["dementia-atlas"],"related":[],"cancers":["alzheimers-disease","mixed-dementia"],"sections":[],"technologies":[],"targets":[],"drugs":["da-lecanemab","da-donanemab"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":["da-bn-trial-exclusion"],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"hypothesis":"A pragmatic trial in people with mixed pathology or common comorbidities can show whether antibody benefit and ARIA risk still justify treatment outside the original label population.","rationale":"Current phase 3 cohorts are cleaner than clinic. Access decisions still hit mixed disease.","test":"Registry-based randomised or well-controlled observational comparison with ARIA and function as co-primary, stratified by vascular burden and anticoagulation.","maturity":"speculative","actor":"research","cost":"large","horizonYears":8},"route":"/ideas/da-idea-inclusive-anti-amyloid-trials/","neighbours":{"cancer":[{"id":"alzheimers-disease","kind":"cancer","name":"Alzheimer’s disease","route":"/diagnoses/alzheimers-disease/"},{"id":"mixed-dementia","kind":"cancer","name":"Mixed dementia","route":"/diagnoses/mixed-dementia/"}],"drug":[{"id":"da-donanemab","kind":"drug","name":"Donanemab","route":"/drugs/da-donanemab/"},{"id":"da-lecanemab","kind":"drug","name":"Lecanemab","route":"/drugs/da-lecanemab/"}],"bottleneck":[{"id":"da-bn-trial-exclusion","kind":"bottleneck","name":"Trial populations that skip mixed disease","route":"/bottlenecks/da-bn-trial-exclusion/"}]}}