{"entity":{"id":"da-memantine","kind":"drug","name":"Memantine","aka":[],"tldr":"Memantine is a tablet used in moderate-to-severe dementia of the Alzheimer’s type. It is a symptom treatment, sometimes combined with a cholinesterase inhibitor.","summary":"Kidney function and dizziness are practical issues. It is not disease-modifying and is not an antibody.","status":"approved","asOf":"2026-09-21","links":[{"label":"DailyMed memantine","url":"https://dailymed.nlm.nih.gov/dailymed/"}],"tags":["dementia-atlas"],"related":[],"cancers":["alzheimers-disease"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"brand":"Namenda","modality":"small molecule","mechanism":"NMDA-receptor antagonist used for cognitive symptoms.","approvals":[{"region":"US","year":2003,"indication":"Moderate-to-severe dementia of the Alzheimer’s type"},{"region":"EU","year":2002,"indication":"Alzheimer’s dementia"},{"region":"UK","year":2002,"indication":"Alzheimer’s dementia"},{"region":"JP","year":2011,"indication":"Alzheimer’s dementia"},{"region":"CN","year":2006,"indication":"Alzheimer’s dementia"},{"region":"AU","year":2004,"indication":"Alzheimer’s dementia"}],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/da-memantine/","neighbours":{"cancer":[{"id":"alzheimers-disease","kind":"cancer","name":"Alzheimer’s disease","route":"/diagnoses/alzheimers-disease/"}]}}