{"entity":{"id":"da-target-tau","kind":"target","name":"Tau","aka":[],"tldr":"Tau is the tangle protein. Its spread tracks symptoms more closely than plaques in many studies.","summary":"Tau therapeutics remain investigational. MAPT mutations are a rare genetic FTD cause.","asOf":"2026-09-21","links":[{"label":"NIA","url":"https://www.nia.nih.gov/health/alzheimers-and-dementia"}],"tags":["dementia-atlas"],"related":[],"cancers":["alzheimers-disease","frontotemporal-dementia"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"symbol":"MAPT","biology":"Microtubule-associated protein that forms neurofibrillary tangles when hyperphosphorylated.","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/da-target-tau/","neighbours":{"cancer":[{"id":"alzheimers-disease","kind":"cancer","name":"Alzheimer’s disease","route":"/diagnoses/alzheimers-disease/"},{"id":"frontotemporal-dementia","kind":"cancer","name":"Frontotemporal dementia","route":"/diagnoses/frontotemporal-dementia/"}],"section":[{"id":"da-front-anti-tau","kind":"section","name":"Anti-tau research","route":"/fronts/da-front-anti-tau/"}],"technology":[{"id":"da-tech-tau-therapeutics","kind":"technology","name":"Tau-directed therapeutics","route":"/technologies/da-tech-tau-therapeutics/"}],"pathway":[{"id":"da-pathway-amyloid-tau","kind":"pathway","name":"Amyloid and tau cascade (simplified)","route":"/pathways/da-pathway-amyloid-tau/"}]}}