{"entity":{"id":"da-target-tdp43","kind":"target","name":"TDP-43","aka":[],"tldr":"TDP-43 is a protein involved in some frontotemporal and related diseases. It is a research target, not a licensed treatment.","summary":"Pathology helps explain FTD heterogeneity. It does not yet yield an approved medicine.","asOf":"2026-09-21","links":[{"label":"NIA: FTD","url":"https://www.nia.nih.gov/health/alzheimers-and-dementia/frontotemporal-disorders"}],"tags":["dementia-atlas"],"related":[],"cancers":["frontotemporal-dementia"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"symbol":"TARDBP","biology":"RNA-binding protein that mislocalises in some FTD and related diseases.","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/da-target-tdp43/","neighbours":{"cancer":[{"id":"frontotemporal-dementia","kind":"cancer","name":"Frontotemporal dementia","route":"/diagnoses/frontotemporal-dementia/"}]}}