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daunorubicin-cytarabine)","route":"/drugs/cpx-351/","recorded":"US approval 2017","registry":"no openFDA label for \"CPX-351\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"dolasetron","name":"Dolasetron","route":"/drugs/dolasetron/","recorded":"US approval 1997","registry":"no openFDA label for \"Dolasetron\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"estramustine","name":"Estramustine","route":"/drugs/estramustine/","recorded":"US approval 1981","registry":"no openFDA label for \"Estramustine\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"fluoxymesterone","name":"Fluoxymesterone","route":"/drugs/fluoxymesterone/","recorded":"US approval 1956","registry":"no openFDA label for \"Fluoxymesterone\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"ga68-dotatate","name":"Gallium-68 DOTATATE (and Cu-64 DOTATATE)","route":"/drugs/ga68-dotatate/","recorded":"US approval 2016","registry":"no openFDA label for \"Gallium-68 DOTATATE\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"gedatolisib","name":"Gedatolisib","route":"/drugs/gedatolisib/","recorded":"US approval 2026","registry":"no openFDA label for \"Gedatolisib\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"hpv-bivalent-vaccine","name":"HPV bivalent vaccine (types 16 and 18)","route":"/drugs/hpv-bivalent-vaccine/","recorded":"US approval 2009","registry":"no openFDA label for \"HPV bivalent vaccine\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"hpv-quadrivalent-vaccine","name":"HPV quadrivalent vaccine (types 6, 11, 16 and 18)","route":"/drugs/hpv-quadrivalent-vaccine/","recorded":"US approval 2006","registry":"no openFDA label for \"HPV quadrivalent vaccine\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"infigratinib","name":"Infigratinib","route":"/drugs/infigratinib/","recorded":"US approval 2021","registry":"no openFDA label for \"Infigratinib\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"interferon-alfa","name":"Interferon alfa-2a/2b","route":"/drugs/interferon-alfa/","recorded":"US approval 1986","registry":"no openFDA label for \"Interferon alfa-2a\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"bcg-intravesical","name":"Intravesical BCG","route":"/drugs/bcg-intravesical/","recorded":"US approval 1990","registry":"no openFDA label for \"Intravesical BCG\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"iobenguane-i-131","name":"Iobenguane I-131 (therapeutic)","route":"/drugs/iobenguane-i-131/","recorded":"US approval 2018","registry":"no openFDA label for \"Iobenguane I-131\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"linvoseltamab","name":"Linvoseltamab","route":"/drugs/linvoseltamab/","recorded":"US approval 2025","registry":"no openFDA label for \"Linvoseltamab\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"lunit-insight-mmg","name":"Lunit INSIGHT MMG","route":"/drugs/lunit-insight-mmg/","recorded":"US approval 2021","registry":"no openFDA label for \"Lunit INSIGHT MMG\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"hepzato","name":"Melphalan hepatic delivery system","route":"/drugs/hepzato/","recorded":"US approval 2023","registry":"no openFDA label for \"Melphalan hepatic delivery system\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"methyl-aminolevulinate","name":"Methyl aminolevulinate","route":"/drugs/methyl-aminolevulinate/","recorded":"US approval 2004","registry":"no openFDA label for \"Methyl aminolevulinate\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"midostaurin","name":"Midostaurin","route":"/drugs/midostaurin/","recorded":"US approval 2017","registry":"no openFDA label for \"Midostaurin\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"mirdametinib","name":"Mirdametinib","route":"/drugs/mirdametinib/","recorded":"US approval 2025","registry":"no openFDA label for \"Mirdametinib\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"mitomycin","name":"Mitomycin C","route":"/drugs/mitomycin/","recorded":"US approval 1974","registry":"no openFDA label for \"Mitomycin C\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"mobocertinib","name":"Mobocertinib","route":"/drugs/mobocertinib/","recorded":"US approval 2021","registry":"no openFDA label for \"Mobocertinib\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"moxetumomab-pasudotox","name":"Moxetumomab pasudotox","route":"/drugs/moxetumomab-pasudotox/","recorded":"US approval 2018","registry":"no openFDA label for \"Moxetumomab pasudotox\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"necitumumab","name":"Necitumumab","route":"/drugs/necitumumab/","recorded":"US approval 2015","registry":"no openFDA label for \"Necitumumab\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"gardasil-9","name":"Nonavalent HPV vaccine","route":"/drugs/gardasil-9/","recorded":"US approval 2014","registry":"no openFDA label for \"Nonavalent HPV vaccine\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"odronextamab","name":"Odronextamab","route":"/drugs/odronextamab/","recorded":"US approval 2025","registry":"no openFDA label for \"Odronextamab\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"olaratumab","name":"Olaratumab","route":"/drugs/olaratumab/","recorded":"US approval 2016","registry":"no openFDA label for \"Olaratumab\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"omacetaxine","name":"Omacetaxine mepesuccinate","route":"/drugs/omacetaxine/","recorded":"US approval 2012","registry":"no openFDA label for \"Omacetaxine mepesuccinate\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"oprelvekin","name":"Oprelvekin","route":"/drugs/oprelvekin/","recorded":"US approval 1997","registry":"no openFDA label for \"Oprelvekin\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"optellum-virtual-nodule-clinic","name":"Optellum Virtual Nodule Clinic","route":"/drugs/optellum-virtual-nodule-clinic/","recorded":"US approval 2021","registry":"no openFDA label for \"Optellum Virtual Nodule Clinic\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"paige-prostate","name":"Paige Prostate Detect","route":"/drugs/paige-prostate/","recorded":"US approval 2021","registry":"no openFDA label for \"Paige Prostate Detect\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"panobinostat","name":"Panobinostat","route":"/drugs/panobinostat/","recorded":"US approval 2015","registry":"no openFDA label for \"Panobinostat\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"peginterferon-alfa-2b","name":"Peginterferon alfa-2b","route":"/drugs/peginterferon-alfa-2b/","recorded":"US approval 2011","registry":"no openFDA label for \"Peginterferon alfa-2b\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"pegylated-liposomal-doxorubicin","name":"Pegylated liposomal doxorubicin","route":"/drugs/pegylated-liposomal-doxorubicin/","recorded":"US approval 1995","registry":"no openFDA label for \"Pegylated liposomal doxorubicin\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"pipobroman","name":"Pipobroman","route":"/drugs/pipobroman/","recorded":"US approval 1966","registry":"no openFDA label for \"Pipobroman\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"plicamycin","name":"Plicamycin","route":"/drugs/plicamycin/","recorded":"US approval 1970","registry":"no openFDA label for \"Plicamycin\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"icad-profound-ai","name":"ProFound AI (iCAD)","route":"/drugs/icad-profound-ai/","recorded":"US approval 2018","registry":"no openFDA label for \"ProFound AI\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"megestrol-progestins","name":"Progestins (megestrol acetate, medroxyprogesterone, levonorgestrel IUD)","route":"/drugs/megestrol-progestins/","recorded":"US approval 1971","registry":"no openFDA label for \"Progestins\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"radioactive-iodine","name":"Radioactive iodine (I-131)","route":"/drugs/radioactive-iodine/","recorded":"US approval 1951","registry":"no openFDA label for \"Radioactive iodine\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"radium-223","name":"Radium-223 dichloride","route":"/drugs/radium-223/","recorded":"US approval 2013","registry":"no openFDA label for \"Radium-223 dichloride\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"samarium-153-lexidronam","name":"Samarium-153 lexidronam","route":"/drugs/samarium-153-lexidronam/","recorded":"US approval 1997","registry":"no openFDA label for \"Samarium-153 lexidronam\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"selpercatinib","name":"Selpercatinib","route":"/drugs/selpercatinib/","recorded":"US approval 2020","registry":"no openFDA label for \"Selpercatinib\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"sirolimus-albumin-bound","name":"Sirolimus protein-bound particles","route":"/drugs/sirolimus-albumin-bound/","recorded":"US approval 2021","registry":"no openFDA label for \"Sirolimus protein-bound particles\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"octreotide-lanreotide","name":"Somatostatin analogues (octreotide, lanreotide)","route":"/drugs/octreotide-lanreotide/","recorded":"US approval 1988","registry":"no openFDA label for \"Somatostatin analogues\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"sunvozertinib","name":"Sunvozertinib","route":"/drugs/sunvozertinib/","recorded":"US approval 2025","registry":"no openFDA label for \"Sunvozertinib\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"tilmanocept-tc99m","name":"Technetium-99m tilmanocept","route":"/drugs/tilmanocept-tc99m/","recorded":"US approval 2013","registry":"no openFDA label for \"Technetium-99m tilmanocept\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"teniposide","name":"Teniposide","route":"/drugs/teniposide/","recorded":"US approval 1992","registry":"no openFDA label for \"Teniposide\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"transpara","name":"Transpara","route":"/drugs/transpara/","recorded":"US approval 2018","registry":"no openFDA label for \"Transpara\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"trastuzumab-biosimilars","name":"Trastuzumab biosimilars","route":"/drugs/trastuzumab-biosimilars/","recorded":"US approval 2017","registry":"no openFDA label for \"Trastuzumab biosimilars\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"umbralisib","name":"Umbralisib","route":"/drugs/umbralisib/","recorded":"US approval 2021","registry":"no openFDA label for \"Umbralisib\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"uracil-mustard","name":"Uracil mustard","route":"/drugs/uracil-mustard/","recorded":"US approval 1962","registry":"no openFDA label for \"Uracil mustard\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"vorasidenib","name":"Vorasidenib","route":"/drugs/vorasidenib/","recorded":"US approval 2024","registry":"no openFDA label for \"Vorasidenib\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"vusolimogene-oderparepvec","name":"Vusolimogene oderparepvec","route":"/drugs/vusolimogene-oderparepvec/","recorded":"US approval 2026","registry":"no openFDA label for \"Vusolimogene oderparepvec\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-approval-no-openfda-label","id":"zanubrutinib","name":"Zanubrutinib","route":"/drugs/zanubrutinib/","recorded":"US approval 2019","registry":"no openFDA label for \"Zanubrutinib\"","url":"https://open.fda.gov/apis/drug/label/","severity":"low"},{"check":"us-first-approval-missing","id":"bevacizumab-glioma","name":"Bevacizumab (glioblastoma use)","route":"/drugs/bevacizumab-glioma/","recorded":"first US approval 2009 (Recurrent glioblastoma (accelerated; full approval 2017))","registry":"Drugs@FDA earliest original approval 2004","url":"https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=Bevacizumab","severity":"low"},{"check":"us-first-approval-missing","id":"dabrafenib-trametinib","name":"Dabrafenib + trametinib","route":"/drugs/dabrafenib-trametinib/","recorded":"first US approval 2014 (BRAF V600E/K unresectable or metastatic melanoma, combination (accelerated; each)","registry":"Drugs@FDA earliest original approval 2013","url":"https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=Dabrafenib","severity":"low"},{"check":"us-first-approval-missing","id":"decitabine-cedazuridine","name":"Decitabine + cedazuridine (oral)","route":"/drugs/decitabine-cedazuridine/","recorded":"first US approval 2020 (MDS and CMML)","registry":"Drugs@FDA earliest original approval 2013","url":"https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=Decitabine","severity":"low"},{"check":"us-first-approval-missing","id":"ifosfamide","name":"Ifosfamide","route":"/drugs/ifosfamide/","recorded":"first US approval 1988 (Germ cell testicular cancer; widely used off-label in sarcoma)","registry":"Drugs@FDA earliest original approval 1987","url":"https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=Ifosfamide","severity":"low"},{"check":"us-first-approval-missing","id":"sodium-thiosulfate","name":"Sodium thiosulfate (otoprotectant)","route":"/drugs/sodium-thiosulfate/","recorded":"first US approval 2022 (Reduce risk of ototoxicity from cisplatin in patients ≥1 month with localised, n)","registry":"Drugs@FDA earliest original approval 2012","url":"https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=Sodium%20thiosulfate","severity":"low"},{"check":"us-first-approval-missing","id":"tretinoin-atra","name":"Tretinoin (all-trans retinoic acid, ATRA)","route":"/drugs/tretinoin-atra/","recorded":"first US approval 1995 (Induction of remission in APL (t(15;17)/PML-RARA))","registry":"Drugs@FDA earliest original approval 1973","url":"https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=Tretinoin","severity":"low"},{"check":"us-first-approval-missing","id":"trifluridine-tipiracil","name":"Trifluridine/tipiracil","route":"/drugs/trifluridine-tipiracil/","recorded":"first US approval 2015 (Refractory metastatic colorectal cancer)","registry":"Drugs@FDA earliest original approval 1995","url":"https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=Trifluridine","severity":"low"}],"errors":[]}