OnCo changelog

OnCo 1.0.0

2026-09-16T00:00:00Z

Public launch. The site is live at https://onco.cc and the repository is the source of record for the corpus.

Added

Glossary: twenty canonical categories (mapped at load from the labels written across the data files), one regular category grid with an animation for every category, and a specific picture on every term that has one (its target's schematic, its molecule, its technology's schematic or the organ it concerns) in the table and at the top of the term page.
Email signup: a SignupBox in the footer and on /newsletter/, driven by NEXT_PUBLIC_SIGNUP_ACTION (Buttondown or Listmonk form endpoint); until it is set the box offers the Atom feed and the per-page Watch button.
Initials placeholder (RowAvatar) for startups, organisations and people without a usable logo or portrait; hotlinked favicons that fail or come back as the generic 16 px globe fall back to it.
Journal wordmarks for Nature, the New England Journal of Medicine, Science and The Lancet from Wikidata via their Wikipedia titles, shown on the journals index and journal pages.
Seventeen ChEMBL drug targets (SRC-family kinases, GM-CSF and IL-11 receptors, xanthine oxidase, DNA polymerase alpha, steroid, serotonin, dopamine, opioid and cannabinoid targets) with HGNC, UniProt and ChEMBL links.
Six NCI-listed supportive-care drugs (eltrombopag, romiplostim, emapalumab, fostamatinib, ravulizumab, propranolol as Hemangeol) from FDA labels; the chlorambucil-prednisone regimen from the ECOG trial; six earlier Cancer Statistics reports as key papers.
Papers for sixty-one leaders and OECI representatives via Europe PMC author and affiliation matching, each set checked against the person's role.

Changed

Provenance tags (gap-fill, chembl-gap, ctgov-ingest, nci-list and similar) are hidden from reader-facing pills and excluded from similarity scoring; they remain in the JSON API.
People pages show one plain-English provenance line under the papers table instead of a fetcher note on every row.
Table cells wrap long tokens site-wide; the models table's paper column uses short labels with the identifier as hover text.
Nine dead organisation websites replaced with verified current addresses; four Wikipedia links repointed to existing articles; every Wikipedia and organisation link in the corpus checked.
NCI drug list credits two-letter regimen acronyms; the completeness matcher no longer drops "AC".

Also in 1.0.0: work unreleased since 0.4.0

#### Added

Molecule3D: ball-and-stick models of small molecules (CPK colours, shaded spheres, depth-sorted bond cylinders with double and triple bonds, drag to rotate, element legend) and smooth backbone ribbons for proteins (Catmull-Rom through the C-alpha trace, per-chain colours, wider on helices and strands, bound drug in ball-and-stick), with a wireframe toggle. Used on product pages, in every molecule thumbnail, and in a new "Solved structures with a drug bound" panel on target pages.
PDB snapshots now keep secondary structure from the HELIX and SHEET records (ss); npm run fetch:structures -- --refresh-pdb 5A9U,5DK3 refreshes chosen entries without touching the rest.
Startups and investors: company records gain optional stage, ycBatch, investors, funding (sourced rounds, amounts only where the source states them) and acquiredBy; companyType: "investor" for venture funds, corporate venture arms, an accelerator and disease foundations, whose portfolios are derived from backlinks.
62 Y Combinator companies attacking cancer, drawn from the open YC directory dataset and checked one by one (src/data/companies-yc.ts, snapshot with every hit and its decision in src/data/universe-lists/yc-oncology.json); 187 further venture-backed oncology companies across therapeutics, diagnostics, AI, digital care, radiotherapy hardware, surgery and tools (src/data/companies-startups.ts); 69 investors (src/data/investors.ts).
/startups/ (stage strip, YC batch chips, filters by stage, modality, cancer, batch, investor and country, most active investors, recently funded) and /investors/; Funding panel on company pages, Portfolio panel on investor pages; stage and investor facets on /companies/; Startups and Investors in the Institutions & people group.

OnCo 0.4.0

2026-09-08T00:00:00Z

Added

Animated wireframe schematics for all 18 fronts (front pages, Fronts index, home) and for all 19 glossary term categories (/terms/ and every term page).
Molecule thumbnails wherever a product is mentioned: cards in pipelines, connected lists, and product tabs; hover popover with the rotating molecule on inline drug chips.
Self-hosted organisation logos under public/logos/ (Wikimedia Commons via Wikidata with domain verification, favicon fallback) for companies, institutions, and collections.
person kind (clinicians and scientists: role, specialisms, profiles, papers) with a People index and a People tab on institution pages.
Site favicon and Apple touch icon; GitHub link in the header.
Public-readiness: CI workflow, issue and pull-request templates, Code of Conduct, security policy, consolidated contributing guide.

Changed

Graph explorer rebuilt as a clean radial view (fronts inner ring, cancers outer ring) with a focus mode that groups neighbours by kind; no physics.
Header language and theme controls are single-line and compact.
Footer and About page carry the work-in-progress disclaimer: verify every fact at its primary source; not medical advice.

OnCo 0.3.0

2026-09-07T00:00:00Z

Added

Deep dives for all 31 cancers (standard of care by setting with NCCN/ESMO guideline mapping, state of the art, history, pipeline, open problems), taking the corpus from 875 to 1574 objects.
Structured trial outcomes on every trial, out-of-100 pictograms, replication notes, and a disclosed evidence score (/evidence/).
Product depth: dosing, label-sourced toxicity tables, cost and access, dated regulatory timelines (/regulatory/), class-wise toxicity comparison (/toxicity/), and animated mechanism cards.
Sourced biomarker prevalence by cancer for targets, with a matrix at /prevalence/.
Browser-only profile with Navigator (line of therapy, cautions, next options), caregiver mode, and a trial finder with country and distance filters.
Reading-level and language layers: plain and simple TL;DRs, translations into Spanish, Chinese, Portuguese, and Hindi (machine-assisted, unreviewed), and glossary hovers.
Power tools: multi-item Compare with differences, Pivot tables, Timeline scrubber, Query builder.
Trust layer: /audit/ (staleness and contradictions), provenance line per record from the commit history, weekly fact checks against openFDA and ClinicalTrials.gov, confidence chips for ideas and speculative roadmap steps, /corrections/ from CORRECTIONS.md, and expert and patient-advocate review tracks with mandatory conflict-of-interest statements.
Visuals: pathway diagrams that light up per product, Body map, theme toggle with high contrast and skip link, Story mode on roadmaps, interactive molecule viewer with nine drug–target PDB complexes, animated process schematics (ADC internalisation, CAR-T, radioligand, and more).
Suggest-an-edit on every page with an organisation self-service track; open evaluation benchmark of 100 questions (/eval/).
Tabbed object pages with the section kept in the URL; grouped navigation (Find, Map, Intelligence, Who, Learn & contribute) with landing pages.
Research output ranking from OpenAlex on /universities/, trial leadership index at /leadership/, cooperative trial groups as institution records, funding flows at /funding/, gaps and bounties at /gaps/, annual report at /report/2026/, and an MCP server (npm run mcp).

Changed

Duplicate entity ids across per-cancer files are merged at load time (first record's scalars win, arrays appended).

OnCo 0.2.0

2026-09-06T00:00:00Z

Added

Slowly rotating 3D wireframes on every product page: small molecules from PubChem 3D conformers, the payload for ADCs, and an IgG C-alpha backbone (PDB 1IGT) for antibodies. Structures are self-hosted under public/structures/.
Organisation logos on company, institution, and collection pages, hotlinked from the organisation's own site.
Filterable, sortable products browser at /drugs/ with phase/status, modality, ADC payload class, front, target, cancer, and company facets, in card or table view.
Explore power view at /explore/: pick a cancer type, switch entity kind, and get a ranked list with a disclosed relevance score.

Changed

"Sections" renamed to "Fronts" (the fronts of the war on cancer); routes moved from /sections/ to /fronts/.
Hero line changed to "Total information dominance on cancer."
The visible "as of" stamp was removed from pages; the internal last-checked date remains in the data for maintainers.

OnCo 0.1.0

2026-09-04T00:00:00Z

Added

Initial release: 642 objects across 14 kinds (cancers, fronts, technologies, targets, products, companies, institutions, pathways, terms, trials, pairings, roadmaps, ideas, collections), one page per object with plain-English TL;DR, derived backlinks, and connected-objects panels.
Triple-negative breast cancer deep dive (the first fully built example): standard of care by setting, state of the art, history timeline, pipeline, open problems.
Nine roadmaps including ADC generations, TROP2 ADCs, TNBC, radiopharmaceuticals, cell therapy, molecular imaging, early detection, immunotherapy, and KRAS.
"For me" cancer picker, institution world map with a disclosed ranking, pathway diagrams, glossary, 50 hub ideas, and a static JSON API at /api/v1/.
Build-time validation of every cross-reference; MIT code licence, CC BY 4.0 data licence.