Donanemab
Donanemab is a monthly infused antibody for early Alzheimer’s disease after amyloid confirmation, with the same ARIA monitoring theme as other amyloid antibodies.
Overview
US approval in 2024 covers mild cognitive impairment or mild dementia due to Alzheimer’s disease after amyloid confirmation. ApoE ε4 changes the ARIA-risk discussion. It is not approved for other dementia subtypes as a disease-modifying treatment.
Amyloid-beta–directed antibody that reduces plaques. The label allows considering stopping after plaques reach minimal levels on PET. Connects to Amyloid-beta.
1.Donanemab binds Amyloid-beta.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 2024 | Early Alzheimer’s disease with confirmed amyloid |
| JP | 2024 | Early Alzheimer’s disease |
| UK | 2024 | Licensed; funding is a separate decision |
| EU | 2025 | Authorisation and national access may differ |
| CN | 2025 | Access may lag the US label |
| AU | 2025 | Access may lag the US label |
Trials
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Landmark trials
Latest papers
topQuery for this drug: (TITLE:"Donanemab" OR ABSTRACT:"Donanemab" OR TITLE:"Kisunla" OR ABSTRACT:"Kisunla") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Donanemab, not a curated reading list.
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