TDP-43

TDP-43 is a protein involved in some frontotemporal and related diseases. It is a research target, not a licensed treatment.

Pathology helps explain FTD heterogeneity. It does not yet yield an approved medicine.

TDP-43: what it is and how drugs act on it · animated generic schematic, not to scale

In plain words · TDP-43 is a protein involved in some frontotemporal and related diseases. It is a research target, not a licensed treatment.

1 · What it is
TDP-43 is a protein involved in some frontotemporal and related diseases. It is a research target, not a licensed treatment.
2 · What goes wrong in cancer
RNA-binding protein that mislocalises in some FTD and related diseases.
3 · How drugs use it
No product in this corpus aims at TDP-43 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.

External identifiers

RNA-binding protein that mislocalises in some FTD and related diseases.

Where it is found

Class

other · TARDBP

Target
Tau
Shares Frontotemporal dementia and the tag dementia-atlas.
Bottleneck
Wrong-subtype treatment
Shares Frontotemporal dementia and the tag dementia-atlas.
Diagnosis
Dementia (umbrella)
Shares Frontotemporal dementia and the tag dementia-atlas.
Diagnosis
Alzheimer’s disease
Shares Frontotemporal dementia and the tag dementia-atlas.