Alzheimer’s disease

What changed: Alzheimer’s disease

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Every dated change on the records linked to Alzheimer’s disease, newest first: approvals and regulatory steps on its medicines, trials that reported, guideline versions, milestones, and when this page itself was checked. Dates come from the records; none is inferred. Orientation, not medical advice.

Approval24Trial result4Milestone5This record1

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September 2026 · 1

2026-09-21This recordAlzheimer’s disease
Facts on this page last checked
When this page itself was last checked or edited.

2024 · 4

2023 · 6

2021 · 1

2021MilestoneAducanumab
Aducanumab accelerated approval
Later withdrawn. Included here so a past approval is not mistaken for a current option.

2019 · 1

2019Trial resultENGAGE
ENGAGE reported
Primary endpoint not met as designed.

2016 · 1

2016Trial resultEXPEDITION 3
EXPEDITION 3 reported
Primary endpoint not met.

2011 · 2

2006 · 2

2004 · 1

2004ApprovalMemantine
Memantine approved in AU
Alzheimer’s dementia

2003 · 1

2003ApprovalMemantine
Memantine approved in US
Moderate-to-severe dementia of the Alzheimer’s type

2002 · 2

2001 · 2

2000 · 2

1999 · 2

1998 · 1

1998ApprovalDonepezil
Donepezil approved in AU
Alzheimer’s dementia

1997 · 2

1996 · 1

1996ApprovalDonepezil
Donepezil approved in US
Dementia of the Alzheimer’s type

1993 · 1

1993MilestoneDonepezil
Tacrine, then safer cholinesterase inhibitors
Symptom treatments entered routine use.

1984 · 1

1984MilestoneAmyloid-beta
Amyloid described as a core plaque protein
The amyloid cascade became a dominant research frame.